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目的探讨甲硝唑联合克林霉素治疗细菌性阴道炎的疗效。方法 110例细菌性阴道炎患者,随机分成对照组(给予甲硝唑治疗)和研究组(给予甲硝唑联合克林霉素治疗),各55例。比较两组治疗效果与复发情况。结果治疗后,对照组痊愈11例,显效17例,有效12例,无效15例,总有效率为72.7%;研究组痊愈15例,显效19例,有效16例,无效5例,总有效率为90.9%;研究组的总有效率高于对照组,差异有统计学意义(χ~2=6.11,P=0.01<0.05)。治疗1个月后复查发现对照组复发率为16.4%,研究组为3.6%,比较差异有统计学意义(P<0.05)。结论采用甲硝唑与克林霉素联合治疗细菌性阴道炎,可以有效地提高临床治疗效果,降低复发率,有效改善预后,值得临床推广应用。
Objective To investigate the curative effect of metronidazole combined with clindamycin in the treatment of bacterial vaginosis. Methods 110 patients with bacterial vaginosis were randomly divided into control group (given metronidazole treatment) and study group (given metronidazole combined with clindamycin treatment), each 55 cases. The treatment effect and recurrence were compared between the two groups. Results After treatment, the control group was cured in 11 cases, markedly effective in 17 cases, effective in 12 cases, ineffective in 15 cases, the total effective rate was 72.7%; study group cured 15 cases, markedly effective in 19 cases, effective in 16 cases, ineffective in 5 cases, the total effective rate (90.9%). The total effective rate of the study group was higher than that of the control group (χ ~ 2 = 6.11, P = 0.01 <0.05). One month after the treatment, the recurrence rate was 16.4% in the control group and 3.6% in the study group, with a significant difference (P <0.05). Conclusion The combination of metronidazole and clindamycin in the treatment of bacterial vaginosis can effectively improve the clinical treatment effect, reduce the recurrence rate and effectively improve the prognosis, worthy of clinical application.