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An international team led by scientists at the Shanghai Institute of Materia Medica(SIMM),CAS has characterized the detailed structure of a receptor that plays a key role in platelet activation and blood clotting.The work has implications for treatment of cardiovascular and other diseases.In a pair of papers published by the journal Nature on May 1st,the scientists provide a detailed map of P2Y12R,a human Gi protein-coupled receptor,in the antagonist and agonist bound states.The antithrombotic drug target has a market of several billion U.S.dollars.“This new work will not only deepen the understanding of activation of this receptor super-family,but will also provide invaluable insight into the improvement and development of P2Y12 drugs targeting cardiovascular and other diseases,”said team leader ZHAO Qiang,professor at SIMM.“I am particularly proud of the high quality international collaboration among China,USA,and
An international team led by scientists at the Shanghai Institute of Materia Medica (SIMM), CAS has characterized the detailed structure of a receptor that plays a key role in platelet activation and blood clotting. The work has implications for treatment of cardiovascular and other diseases. In a pair of papers published by the journal Nature on May 1st, the scientists provide a detailed map of P2Y12R, a human Gi protein-coupled receptor, in the antagonist and agonist bound states. The antithrombotic drug target has a market of several billion US dollars. ”This new work will not only deepen the understanding of activation of this receptor super-family, but also provide invaluable insight into the improvement and development of P2Y12 drugs targeting cardiovascular and other diseases, “ said team leader ZHAO Qiang, professor at SIMM. ”I am particularly proud of the high quality international collaboration among China, USA, and