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目的探讨透明质酸钠联合雌激素预防人工流产术后子宫内膜炎临床效果,为临床诊治提供参考。方法选择2012年12月-2014年3月杭州市妇产科医院收治的80例人工流产患者,按照数字表法分为对照组与观察组,各40例。对照组人工流产术后使用雌激素预防子宫内膜炎发生,观察组人工流产术后使用雌激素联合透明质酸钠预防子宫内膜炎发生,分别于治疗后1周、2周对比两组患者子宫内膜炎症状评分、宫颈分泌物炎症指标。结果观察组与对照组治疗前后白带增多、腹痛、发热症状评分均有显著改善(P<0.05),治疗后1周、治疗后2周观察组白带增多、腹痛、发热症状评分改善均优于对照组(P<0.05);观察组与对照组治疗前后CRP、IL-6、IL-8均有显著改善(P<0.05),治疗后1周、治疗后2周观察组CRP、IL-6、IL-8改善均优于对照组(P<0.05)。结论透明质酸钠联合雌激素可以有效预防人工流产术后子宫内膜炎发生,值得临床推广应用。
Objective To investigate the clinical effects of sodium hyaluronate combined with estrogen in the prevention of endometritis after induced abortion and provide reference for clinical diagnosis and treatment. Methods Eighty cases of induced abortion admitted from December 2012 to March 2014 in Hangzhou Obstetrics and Gynecology Hospital were divided into control group and observation group according to digital table method, 40 cases in each group. In the control group, estrogen was used to prevent endometritis after induced abortion. In the observation group, estrogen combined with sodium hyaluronate was used to prevent the occurrence of endometritis after induced abortion. The patients in the two groups were compared at week 1 and 2 after treatment Endometritis symptoms score, cervical secretions inflammation indicators. Results Before and after treatment, the leucorrhea increased, the scores of abdominal pain and fever were significantly improved in the observation group and the control group (P <0.05). After 1 week of treatment, the leucorrhea in the observation group increased more than that of the control group (P <0.05). The levels of CRP, IL-6 and IL-8 in the observation group and the control group were significantly improved after treatment (P <0.05) IL-8 improved better than the control group (P <0.05). Conclusion Sodium hyaluronate combined with estrogen can effectively prevent endometritis after induced abortion, which is worthy of clinical application.