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为了探讨肝转移形成机制和生物学特性,用人类鼻咽癌(CNE—2Z)和小鼠子宫颈癌(U14)分别在裸鼠和615近交系小鼠脾内移植。结果人类鼻咽癌脾内移植后43—50天有8/10例(80％)在脾一端形成瘤结节的同时肝内也形成转移瘤,其中4例合并肺转移;小鼠子宫颈癌在615小鼠脾内移植后,13—14天处死,结果1和3天切除原发瘤,分别有11％和63％发生了肝转移,而未切除原发瘤有73％发生肝转移。同时有程度不等的肺和淋巴结转移。结果表明凡有足够的癌细胞接种到脾内均可发生原发瘤,继而沿血流系统进入肝脏,在肝内形成转移瘤。
In order to investigate the mechanism of liver metastasis and biological characteristics, human nasopharyngeal carcinoma (CNE-2Z) and mouse cervical cancer (U14) were transplanted in nude mice and 615 inbred mice respectively. RESULTS: Eight to 10 (80%) of 43-50 days after transplantation of human nasopharyngeal carcinoma resulted in the formation of nodules in the spleen at one end of the spleen and metastases in the liver, of which 4 cases were associated with lung metastasis. Mouse cervical cancer After transplanting in 615 mice spleens, they were sacrificed on days 13-14. As a result, primary tumors were resected on days 1 and 3, with hepatic metastases in 11% and 63%, respectively, and in 73% of non-resected primary tumors. At the same time, varying degrees of lung and lymph node metastases. The results show that where enough cancer cells inoculated into the spleen can occur primary tumor, followed by the bloodstream system into the liver, the formation of metastases in the liver.