论文部分内容阅读
The Janus kinase-signal transducers and activators of transcription(JAK-STAT)signaling pathway,activated bymore than 50 cytokines or growth factors,plays critical roles in a wide variety of cellular functions in thehematopoietic,immune,neuronal and hepatic systems.In the liver,this signaling pathway,activated by more than20 cytokines,growth factors,hormones,and hepatitis viral proteins,plays critical roles in antiviral defense,acutephase response,hepatic injury,repair,inflammation,transformation,and hepatitis.This article reviews thebiological significance of STAT1,2,3,4,5,6 in hepatic functions and diseases.Cellular & Molecular Immunology.2005;2(2):92-100.
The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway, activated bymore than 50 cytokines or growth factors, plays critical roles in a wide variety of cellular functions in the hematopoietic, immune, neuronal and hepatic systems. The liver , this signaling pathway, activated by more than 20 cytokines, growth factors, hormones, and hepatitis viral proteins, plays a critical role in antiviral defense, acute phase response, hepatic injury, repair, inflammation, transformation, and hepatitis. This article reviews the biological significance of STAT1 , 2,3,4,5,6 in hepatic functions and diseases. Cellular & Molecular Immunology. 2005; 2 (2): 92-100.