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目的 探讨狼疮性肾炎 (L N)患者外周血淋巴细胞亚群、活化状态和免疫球蛋白的变化及其相互关系 .方法 采用流式细胞仪和酶联检测仪对 2 1例 L N进行了研究 .结果 1L N患者 CD3+ +CD4 + (0 .2 4± 0 .10 ) ,CD4 5 RA+ (0 .2 9± 0 .0 6 ) ,CD4 5 RO+ (0 .0 2± 0 .0 2 ) ,CD4 + +CD4 5 RA+ (0 .11± 0 .0 6 ) ,CD4 + CD4 5 RO+ (0 .0 5± 0 .0 4 )细胞比例明显减少 ,与对照组 (0 .4 1± 0 .0 9,0 .4 5± 0 .11,0 .0 5± 0 .0 5 ,0 .2 1±0 .0 7,0 .0 8± 0 .0 2 )比较 P<0 .0 5 ,P<0 .0 1;2 L N患者 HL A-DR+ (0 .13± 0 .0 4 ) ,CD19+ +HL A- DR+ (0 .0 8± 0 .0 3) ,CD19+ +CD4 3+ (0 .0 3± 0 .0 2 ) ,CD19+ +CD5 + (0 .0 5± 0 .0 2 )细胞比例明显增高 ,与对照组 (0 .0 6± 0 .0 4 ,0 .0 4± 0 .0 4 ,0 .0 1± 0 .0 0 4 ,0 .0 1± 0 .0 1)比较 P<0 .0 5 ,P<0 .0 1;3L N患者 Ig E水平明显升高 ,与对照组 (81± 4 0 ) k U· L- 1 相比 ,NS组 (46 7± 2 99) k U· L- 1 P<0 .0 1,非 NS组 (2 2 4± 15 1) k U·L- 1 P<0 .0 5 ,两组比较 P<0 .0 5 ;Ig M,NS组 (3.7± 2 .0 )g· L- 1 ,非 NS组 (3.6± 2 .9) g· L- 1 ;Ig A,NS组 (4.7±1.1) g· L- 1 ,非 NS组 (4.1± 2 .0 ) g· L- 1 水平也升高 (P<0
Objective To investigate the changes of peripheral blood lymphocyte subsets, activation status and immunoglobulin in patients with lupus nephritis (LN) and their relationship.Methods Twenty-one cases of LN were studied by flow cytometry and enzyme-linked detector.Results CD3 + + CD4 + (0.24 ± 0.10), CD4 + RA + (0.29 ± 0.06), CD4 + RO + (+0.2 ± 0.02), CD4 + + CD4 + RA + (0.11 ± 0.06), CD4 + CD4 + RO + (+0.5 + -0.4) cells significantly decreased compared with the control group (0.41 ± 0.09, 0 .4 5 ± 0 .11,0 .0 5 ± 0 .0 5, 0 .2 1 ± 0 .0 7,0 .0 8 ± 0 .0 2) Comparing P <0 .0 5, P <0 (0 .13 ± 0. 04), CD19 + + HL A-DR + (0.08 ± 0.30), CD19 + + CD4 3+ (0 .03 ± 0 .0 2). The percentage of CD19 + + CD5 + (0. 05 ± 0. 0 2) cells was significantly higher than that of the control group (0.60 ± 0.40, 0.40 ± 0.40 , 0 .1 ± 0 .0 0 4,0 0 1 ± 0 .0 1) compared P <0. 05, P <0. 01; 3L N patients IgE levels were significantly increased, and the control group NS group (46 7 ± 2 99) kU · L -1 P <0.01, non-NS group (22 4 ± 15 1) k U · L-1 P <0. 05, P <0. 05 for both groups ; Ig M, NS group (3.7 ± 2.0) g · L -1, non-NS group (3.6 ± 2.9) g · L -1; , And non-NS group (4.1 ± 2.0) g · L-1 also increased (P <0