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目的研究两种粪便生物标记物乳铁蛋白、钙卫蛋白诊断溃疡性结肠炎(ulcerative colitis,UC)活动性的价值。方法选择确诊的UC患者72例作为研究组,60例经结肠镜检查均正常的患者作为对照组,留取结肠镜检查3 d内的粪便样本5~10 g,应用ELISA方法进行粪便乳铁蛋白、钙卫蛋白检测。结果粪便乳铁蛋白、钙卫蛋白水平在缓解组和对照组之间比较差异均无统计学意义(P>0.05);活动组分别与缓解组和对照组比较差异均有显著统计学意义(P<0.01);活动期各组之间相互比较差异均有统计学意义(P<0.01)。粪便乳铁蛋白、钙卫蛋白水平与UC内镜分级标准呈正相关(r=0.873;0.891,P<0.01)。结论粪便乳铁蛋白、钙卫蛋白检测能够较准确地诊断UC活动期和缓解期,对临床治疗有指导作用。
Objective To investigate the diagnostic value of two fecal biomarkers, lactoferrin and calprotectin, on the activity of ulcerative colitis (UC). Methods Seventy-two patients with confirmed UC were selected as the study group and 60 patients with normal colonoscopy were selected as the control group. The stool samples were collected within 5 days after colonoscopy. The stool lactoferrin , Calprotectin test. Results Fecal lactoferrin and calprotectin levels were not significantly different between the remission group and the control group (P> 0.05), and there was significant difference between the active group and the remission group and the control group (P <0.01). There was significant difference between each group during active stage (P <0.01). Fecal lactoferrin and calprotectin levels were positively correlated with UC endoscopic grading standards (r = 0.873; 0.891, P <0.01). Conclusion Fecal lactoferrin and calprotectin can be used to diagnose the active stage and remission stage of UC more accurately and have a guiding effect on clinical treatment.