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卵巢癌是女性生殖系统恶性肿瘤病死率最高的疾病,多药耐药现象在卵巢癌治疗中普遍存在,严重影响治疗效果及卵巢癌患者的生存率。基因测序技术及生物信息学的迅猛发展使精确寻找癌症发生发展的关键靶点成为可能,分子进化理论研究为此提供了重要的理论及技术支持。卵巢癌患者及耐药相关突变基因包括P53基因、BRCA1/BRCA2基因等等。分子进化理论可在确定导致癌症发生或耐药的关键突变位点方面提供新思路,该理论有助于从新的方向阐释癌细胞耐药的相关机制,从而更有针对性地提出治疗的有效措施。
Ovarian cancer is the highest mortality rate of malignant tumors in female reproductive system. The multidrug resistance phenomenon is ubiquitous in the treatment of ovarian cancer, which seriously affects the therapeutic effect and the survival rate of patients with ovarian cancer. The rapid development of gene sequencing technology and bioinformatics makes it possible to find out exactly the key targets for the development of cancer. The theory of molecular evolution provides important theoretical and technical support for this. Ovarian cancer patients and resistance-related mutations include the P53 gene, BRCA1 / BRCA2 gene and so on. The theory of molecular evolution can provide new ideas in determining the key mutation sites that lead to cancer or drug resistance. This theory can help elucidate the mechanisms of cancer drug resistance in a new direction, so as to propose more effective measures for treatment .