论文部分内容阅读
目的：测定口服左氟沙星后的血清和胆汁的杀菌效价。方法：采用微量平板稀释法。结果：左氟沙星对链球菌、变形杆菌、肺炎克雷伯氏菌有强大的杀菌活性，且杀菌作用能维持在８ｈ以上；对大肠埃希氏菌、金黄色葡萄球菌也具有良好的杀菌作用，其杀菌作用也能维持８ｈ以上，但其血清杀菌效价为１４，对绿脓假单胞菌的杀菌作用较低，８ｈ后无作用。结论：左氟沙星对胆道的链球菌、肺炎克雷伯氏菌、变形杆菌、大肠杆菌、金黄色葡萄球菌有较好的杀菌作用，对绿脓假单胞菌作用较差。
OBJECTIVE: To determine the bactericidal titer of serum and bile after oral administration of levofloxacin. Methods: Micro-plate dilution method. Results: Levofloxacin against Streptococcus, Proteus, Klebsiella pneumoniae has a strong bactericidal activity, and the bactericidal effect can be maintained over 8h; Escherichia coli, Staphylococcus aureus also has a good bactericidal Role, its bactericidal effect can be maintained over 8h, but the serum bactericidal titer of 14, the bactericidal effect of Pseudomonas aeruginosa is low, no effect after 8h. Conclusion: Levofloxacin has good bactericidal effect on streptococcus bilis, Klebsiella pneumoniae, Proteus, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.