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本文采用放射免疫分析方法,测定了42例膀胱癌患者,13例尿路感染患者,13例身体其它部位恶性肿瘤患者和52例正常人尿液中β_2微球蛋白(简称β_2—mG)的含量。被测者血清肌酐值等于或小于105mmOL/L,以排除由于肾机能损害而引起的尿液中β_2—mG 值增高。由于4组间尿液中β_2—mG 的含量差异显著,并且尿液中β_2—mG 含量变化与膀胱癌的分期有关,随着肿瘤浸润深度的增加其测得值增高。故认为尿液中β_2—mG 的测定对膀胱癌的早期诊断、预后估计及术后随访的意义较大,可作为膀胱癌高发人群中一项快速、简便、无损伤的筛选检查。
In this paper, radioimmunoassay was used to determine the content of β_2 microglobulin (β_2-mG) in urine of 42 patients with bladder cancer, 13 patients with urinary tract infection, 13 patients with malignant tumor in other parts of the body and 52 normal persons . The measured serum creatinine value is equal to or less than 105mmOL / L, to exclude due to renal impairment caused by urine β_2-mG value increased. The content of β_2-mG in urine was significantly different among 4 groups, and the change of β_2-mG in urine was related to the stage of bladder cancer. The measured value increased as the depth of tumor infiltration increased. Therefore, the determination of β_2-mG in urine is of great significance for early diagnosis, prognosis estimation and follow-up of bladder cancer, and can be used as a fast, simple and non-invasive screening test in bladder cancer with high incidence.