亚硒酸钠目前已被广泛应用于防治大骨节病和克山病,且疗效显著。开发高效低毒、安全的硒制剂供临床使用业已引起化学家、生物化学家、微生物学家、临床医学和畜牧兽医学家、药理学家等广泛的兴趣,近年也取得了一定进展。富硒酵母作为一种生物硒制剂已在美国市场上出售,据报导其含硒量为每片50～200μg,但其在人体内的利用率、毒 Sodium selenite has now been widely used in the prevention and treatment of Kashin-Beck disease and Keshan disease, and a significant effect. The development of efficient, low-toxic and safe selenium preparations for clinical use has attracted widespread interest among chemists, biochemists, microbiologists, clinical medicine and animal husbandry and veterinary scientists and pharmacologists and some progress has been made in recent years. Selenium-enriched yeast, as a bio-selenium preparation, has been marketed in the United States, with selenium levels reported to be 50-200 μg per tablet but its availability in the human body,