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Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) following a simple exposure technique. A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the vapor thus generated was purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y=50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate,and may also prove useful in evaluating irritation of upper respiratory tract fOllowing the inhalation of vapors of various chemicals.
Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f) -1,4 oxazepine (CR) following a simple A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the solution thus purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y = 50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate, and may also prove useful in evaluating irritation of upper respiratory tract fOllowing th e inhalation of vapors of various chemicals.