The human skull, composed of tabula externa, tabula interna, and a porous diploe sandwiched in between, is deformed with changing intracranial pressure (ICP). Because the human skull’s thickness is only 6 mm, it is simplified as a thin-walled shell. The objective of this article is to analyze the strain of the thin-walled shell by the stress-strain calculation of a human skull with changing ICP. Under the same loading conditions, using finite element analysis (FEA), the strains of the human skull were calculated and the results were compared with the measurements of the simulative experiment in vitro. It is demonstrated that the strain of the thin-walled shell is totally measured by pasting the one-way strain foils on the exterior surface of the shell with suitable amendment for data. The amendment scope of the measured strain values of the thin-walled shell is from 13.04% to 22.22%. The human skull, composed of tabula externa, tabula interna, and a porous porous sandwiched in between, is deformed with changing intracranial pressure (ICP). Because the human skull’s thickness is only 6 mm, it is simplified as a thin-walled shell. The objective of this article is to analyze the strain of the thin-walled shells by the stress-strain calculation of a human skull with changing ICP. Under the same loading conditions, using finite element analysis (FEA), the strain of the human skull were calculated and the results were compared with the measurements of the simulative experiment in vitro. It is said that the strain of the thin-walled shell is totally measured by the one-way strain foils on the exterior surface of the shell with a suitable amendment. for data. The amendment scope of the measured strain values ​​of the thin-walled shell is from 13.04% to 22.22%.