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大鼠延髓腹侧面头端应用毒扁豆碱引起血压升高和心率加快,伴有延髓腹侧面头端胆碱酯酶活性降低和脊髓蛛网膜下腔灌流液中P物质样免疫反应活性升高。在延髓腹侧面头端应用阿托品或脊髓蛛网膜下腔注射P物质拮抗剂D-脯~2,D-苯丙~7,D-色~9-P物质均可阻断毒扁豆碱的心血管效应。脊髓蛛网膜下腔注射P物质抗血清或辣椒素均可减弱毒扁豆碱的升压反应。实验结果提示,毒扁豆碱作用于延髓腹侧面头端的M受体,兴奋了延髓-脊髓P物质能神经元下行通路,使之释放P物质,引起交感肾上腺髓质系统兴奋,从而使血压升高和心率加快。
The application of physostigmine in the rostral ventrolateral medulla caused a rise in blood pressure and heart rate, accompanied by a reduction of cholinesterase activity in the ventral medulla oblongata and increased substance P-like immunoreactivity in spinal cord subarachnoid perfusate. Application of atropine or spinal subarachnoid injection of P substance antagonist D-preservative ~ 2, D-phenylpropane ~ 7, D-color ~ 9-P substance in the medulla oblongata head side can block the plasma of physostigmine effect. Spinal subarachnoid injection of substance P antiserum or capsaicin can be reduced physostigmine pressure response. The experimental results suggest that physostigmine acts on the M receptor in the medulla oblongata and excites the downstream pathway of medulla oblongata-P neurons in spinal cord to release substance P, which excites the sympathetic adrenal system to increase blood pressure And heart rate faster.