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目的 :研究上皮钙粘素 (E- cadherin,E- cad)在非小细胞肺癌中的表达 ,探讨 E- cad表达与组织类型、细胞分化程度、淋巴结转移及预后的关系。方法 :采用 S- P免疫组化方法 ,检测 6 5例非小细胞肺癌中 E- cad的表达情况。结果 :6 5例非小细胞肺癌中 E- cad的异常表达率为 86 .2 % ,其表达与组织学类型间无关 (P >0 .0 5 ) ,与分化程度、淋巴结转移、术后生存时间显著相关 (P <0 .0 5 ) ,并与非小细胞肺癌患者的预后显著相关 (P <0 .0 5 )。结论 :E- cad表达异常可能与非小细胞肺癌的恶变过程有关 ,可作为判断非小细胞肺癌恶性程度及预后的指标。
Objective: To investigate the expression of E-cadherin (E-cad) in non-small cell lung cancer (NSCLC) and to explore the relationship between E-cadherin expression and tissue type, cell differentiation, lymph node metastasis and prognosis. Methods: The expression of E-cadherin in 65 cases of non-small cell lung cancer was detected by S-P immunohistochemistry. Results: The abnormal expression rate of E-cad in 65 non-small cell lung cancer patients was 86.2%. The expression of E-cad was not related to the histological type (P> 0.05), but correlated with the degree of differentiation, lymph node metastasis, postoperative survival (P <0.05), which was significantly correlated with the prognosis of patients with non-small cell lung cancer (P <0.05). Conclusion: The abnormal expression of E-cad may be related to the malignant transformation of non-small cell lung cancer, which can be used as an index to judge the malignancy and prognosis of non-small cell lung cancer.