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1948年Farber首先应用抗叶酸制剂治疗急性白血病(简称急白),开辟了白血病化学治疗的途径。至1964年仍为单一药物治疗时期,其完全缓解率低于15％,生命延长不及一年。近10多年来,化疗药物逐日增多,联合化疗迅速发展,疗效不断提高,存活5年以上的病例已不鲜见。联合化疗对急白的可喜的疗效与细胞动力学的研究有一定关系。本文就有关问题进行概述。细胞动力学的研究及化疗药物的作用细胞动力学的研究证明:无论正常或白血病组织均由三种不同的细胞群组成:(1)进行分裂的细胞(增殖细胞),其分裂周期可分为四期:DNA合成前期(G_1期)、DNA合成
1948 Farber first application of anti-folic acid preparations for the treatment of acute leukemia (referred to as acute white), opened up a leukemia chemotherapy approach. To 1964 is still single drug treatment period, the complete remission rate of less than 15%, life less than a year. In the recent 10 years, chemotherapeutic drugs have been increasing day by day. The rapid development of combined chemotherapy and continuous improvement of the curative effect have not been rare. The favorable curative effect of combined chemotherapy on acute whiteness has something to do with the research of cell kinetics. This article gives an overview of the issues involved. Cell kinetics and the role of chemotherapeutic drugs Cytokinetic studies have shown that: normal or leukemia organizations are composed of three different cell populations: (1) division of cells (proliferating cells), the division cycle can be divided For the four phases: pre-DNA synthesis (G_1 phase), DNA synthesis