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目的探讨瘦素受体基因Lys109Arg多态性与非酒精性脂肪性肝病(NAFLD)的关系。方法收集180 例接受体检的成年人,分成2组:(1)NAFLD组117例,男77例,女40例,平均年龄(50．4±13．1)岁;(2)对照组63例,男32例,女31例,平均年龄(49．1±14．5)岁。同时测定身高、体重、臀围、腰围、腹壁脂肪厚度、体脂含量、血压。入选对象均签署知情同意书。试验对象进行空腹采血,血标本用于检测丙氨酸氨基转移酶、甘油三酯、高密度脂蛋白和血糖水平。结果NAFLD患者和正常对照组LEPR基因Lys109Lys、Lys109Arg和Arg109Arg多态性分布差异无统计学意义(x2=1．409,P=0．494)。腹壁脂肪厚度LEPR基因Lys109Lys携带者平均为(4．1± 0．4)cm,Lys109Arg平均为(2．8±0．6)cm,Arg109Arg平均为(2．7±0．7)cm,LEPR基因Lys109Lys携带者明显高于Lys109Arg和Arg109Arg携带者,差异有统计学意义(F 5．197,P=0．006)。血清胆固醇水平LEPR 基因Lys109Lys携带者平均为(5．1±0．4)mmol／L,Lys109Arg平均为(25．5±6．9)mmol／L,Arg109Arg平均为(27．2±8．4)mmol／L,LEPR基因Lys109Lys携带者明显降低,差异有统计学意义(F=8．164,P=0．005)。结论瘦素受体基因Lys109Arg多态性可能参与腹壁脂肪的分布和胆固醇代谢的调节,至于是否参与NAFLD的发病机制尚待进一步研究。
Objective To investigate the relationship between leptin receptor gene Lys109Arg polymorphism and non-alcoholic fatty liver disease (NAFLD). Methods One hundred and seventy adults who underwent physical examination were collected and divided into two groups: (1) 117 NAFLD patients, 77 males and 40 females, with an average age of (50.4 ± 13.1) years; (2) , 32 males and 31 females, with an average age of (49.1 ± 14.5) years. Simultaneous determination of height, weight, hip circumference, waist circumference, abdominal fat thickness, body fat content, blood pressure. Informed consent is given to all the participants. The subjects were fasting blood samples were taken for the detection of alanine aminotransferase, triglyceride, high density lipoprotein and blood glucose levels. Results There was no significant difference in the distribution of LysR9Lys, Lys109Arg and Arg109Arg among patients with NAFLD and normal control (x2 = 1.409, P = 0.494). The average thickness of Lys109Lys was (4.1 ± 0.4) cm, the average Lys109Arg was (2.8 ± 0.6) cm, the average Arg109Arg was (2.7 ± 0.7) cm and the LEPR The carrier of Lys109Lys gene was significantly higher than that of Lys109Arg and Arg109Arg carriers (F 5.197, P = 0.006). Serum cholesterol levels LEPR gene Lys109Lys carrier average (5.1 ± 0.4) mmol / L, Lys109Arg average (25.5 ± 6.9) mmol / L, Arg109Arg average (27.2 ± 8.4 ) mmol / L, LEPR gene Lys109Lys carrier was significantly lower, the difference was statistically significant (F = 8.164, P = 0.005). Conclusion Leptin receptor gene Lys109Arg polymorphism may be involved in the distribution of abdominal fat and cholesterol metabolism, as to whether the pathogenesis of NAFLD remains to be further studied.