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目的:探讨上皮型钙粘素(E-cadherin,E-cad)和β-连环素(β-catenin,β-cat)在食管鳞状细胞癌(ESCC)中的表达及其与临床病理特征的关系。方法:采用免疫组织化学En Vision法检测60例ESCC组织和15例正常食管组织中E-cad和β-cat的表达,分析其表达与ESCC临床病理特征的关系。结果:(1)E-cad和β-cat在ESCC组织中的异常表达率分别为61.67%(37/60)和66.67%(40/60),高于正常食管组织(0.00%,0.00%)(P<0.01);(2)E-cad和β-cat在中低分化、侵及肌层及有淋巴结转移患者中的异常表达率分别高于高分化、未侵及肌层及无淋巴结转移患者(P<0.01);(3)ESCC中E-cad和β-cat的表达呈正相关(r=0.679,P<0.01)。结论:ESCC中E-cad和β-cat异常表达促进了肿瘤的浸润和发展,可能作为监测肿瘤恶性程度和判断预后的指标。
Objective: To investigate the expression of E-cadherin and β-catenin in esophageal squamous cell carcinoma (ESCC) and its relationship with clinicopathological features relationship. Methods: The expressions of E-cad and β-cat in 60 ESCC tissues and 15 normal esophageal tissues were detected by immunohistochemistry En Vision method. The relationship between E-cad and β-cat expression and the clinicopathological features of ESCC was analyzed. Results: (1) The abnormal expression rates of E-cad and β-cat in ESCC tissues were 61.67% (37/60) and 66.67% (40/60), respectively, which were higher than those in normal esophagus tissues (0.00%, 0.00% (P <0.01). (2) The abnormal expression rates of E-cad and β-cat in moderately poorly differentiated, invasive muscularis and patients with lymph node metastasis were significantly higher than those in well differentiated, non-invasive muscularis and without lymph node metastasis (P <0.01). (3) The expression of E-cad and β-cat in ESCC was positively correlated (r = 0.679, P <0.01). Conclusion: The abnormal expression of E-cad and β-cat in ESCC promotes the infiltration and development of the tumor, which may be used as an indicator to monitor the malignancy and prognosis.