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目的:研究中药组方对阴虚内热型系统性红斑狼疮的疗效及对Th1/Th2平衡的调节作用,为临床治疗提供依据。方法:选取2014年12月—2015年12月我院收治的系统性红斑狼疮患者90例,按照随机数字表法将患者分为研究组和对照组,每组45例,对照组给予常规西药治疗,研究组在对照组的基础上给予中药组方治疗,测量两组治疗前后血清白细胞介素-2(IL-2)、白细胞介素-4(IL-4)和白细胞介素-10(IL-10)水平,比较两组治疗前、后SLEDAI评分和中医证候评分,并比较两组临床疗效。结果:研究组总有效率77.78%(35/45)显著高于对照组的46.67%(21/45),比较差异具有统计学意义(P<0.05);治疗前两组IL-2、IL-4和IL-10比较无统计学意义(P>0.05),治疗后两组IL-2显著增加,IL-10显著降低,且研究组IL-2高于对照组,IL-10低于对照组,比较差异具有统计学意义(P<0.05),治疗前两组IL-4比较无统计学意义(P>0.05),治疗后研究组IL-4显著降低,对照组IL-4明显增加,比较差异具有统计学意义(P<0.05);治疗前两组SLEDAI评分和中医证候评分比较无统计学意义(P>0.05),治疗后两组SLEDAI评分和中医证候评分显著降低,且研究组显著低于对照组,比较差异具有统计学意义(P<0.05)。结论:中药组方治疗阴虚内热型系统性红斑狼疮具有较好的临床疗效,对Th1/Th2的平衡具有调节作用。
Objective: To study the curative effect of traditional Chinese medicine prescription on the febrile endogenous heat-type systemic lupus erythematosus and the regulation of Th1 / Th2 balance in order to provide the basis for clinical treatment. Methods: Totally 90 patients with systemic lupus erythematosus admitted from December 2014 to December 2015 in our hospital were divided into study group (n = 45) and control group (n = 45) according to random number table method. Patients in control group were given conventional western medicine , The study group was given the traditional Chinese medicine prescription on the basis of the control group, and the levels of serum interleukin-2, interleukin-4 (IL-4) and interleukin-10 -10). The SLEDAI score and TCM syndrome score were compared between the two groups before and after treatment, and the clinical efficacy was compared between the two groups. Results: The total effective rate of the study group was 77.78% (35/45), significantly higher than that of the control group (46.67%, 21/45), the difference was statistically significant (P <0.05) 4 and IL-10 were not statistically significant (P> 0.05). After treatment, the levels of IL-2 and IL-10 in the two groups significantly increased, while the levels of IL-2 in the study group were higher than those in the control group (P <0.05). The levels of IL-4 in the two groups before treatment were not significantly different (P> 0.05). After treatment, the levels of IL-4 in the study group were significantly decreased, and the levels of IL-4 in the control group were significantly increased (P <0.05). There was no significant difference in SLEDAI score and TCM syndrome score between the two groups before treatment (P> 0.05). After treatment, the SLEDAI score and TCM syndrome score decreased significantly in both groups Significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: The traditional Chinese medicine prescription for the treatment of Yin deficiency endogenous heat systemic lupus erythematosus has a good clinical efficacy, the balance of Th1 / Th2 play a regulatory role.