药物从制剂中以受控形式恒速地释放到作用器官或特定靶器官而发挥治疗作用的一类制剂称控释制剂~[1～3](COntrolled releasedosage forms,以下简称CRDF)。近二十年来逐渐应用于临床。CRDF有片剂、胶囊剂、注射剂、软膏剂、透皮吸收粘贴剂、阴道剂等剂型,而以口服剂型的片剂与胶囊剂为最 A class of agents that exert a therapeutic effect from a formulation at a constant rate of release in a controlled manner to a targeted organ or a specific target organ is referred to as a controlled release formulation [1-3] (CRDF). Over the past 20 years gradually applied to clinical. CRDFs are in the form of tablets, capsules, injections, ointments, transdermal patches, vaginal preparations and the like, while tablets and capsules in oral dosage form are the most