本文介绍了５，１０－亚甲基四氢叶酸还原酶的生化功能和基因结构、基因突变及多态性位点，重点介绍了５，１０－亚甲基四氢叶酸还原酶与神经管畸形关系的研究进展 This article describes the 5,10-methylenetetrahydrofolate reductase biochemical function and gene structure, gene mutations and polymorphic sites, focusing on the 5,10-methylenetetrahydrofolate reductase and neural tube defects Research progress of the relationship