采用聚乙二醇４００制备了尼群地平软胶丸，其体外溶出度高于市售片剂。９名健康受试者交叉口服胶丸剂和片剂，胶丸剂的达峰时间（Ｔｍａｘ）明显提前，峰浓度（Ｃｍａｘ）增高，药时曲线下面积（ＡＵＣ）值增加，经统计学分析，两制剂的生物利用度有显著性差异。 Poly (ethylene glycol) 400 was used to prepare nitrendipine soft capsules with higher dissolution rate in vitro than the commercial tablets. Nine healthy volunteers crossed the oral cavity with the pills and tablets. The peak time (Tmax), the peak concentration (Cmax) and the area under the curve (AUC) of the capsules increased significantly. According to the statistical analysis, There was a significant difference in the bioavailability of the formulations.