抗胆碱能药物已广泛地用于十二指肠溃疡的治疗。它虽可降低基础的、夜间的或刺激后胃酸的排泌,但由于常用的治疗剂量常引起广泛的副交感神经阻滞所致的副作用而受到严重的限制。可能是药物的血浆浓度超过了抑制胃酸分泌所需要的浓度。这种现象在使用传统方法时很难避免。作者应用抗胆碱能药物～甲溴东莨菪碱,采取一种新的经皮肤导入治疗方法,使用CIBA药品公司生产的治疗仪(transde rm V.),它可以使药物按予先确定的控制速率从皮肤进入血液循环,以观察对十二指 Anticholinergic drugs have been used extensively for the treatment of duodenal ulcers. Although it can reduce basal, nocturnal, or stimulated gastric acid secretion, it is severely limited by the often-used therapeutic doses that often cause side effects of extensive parasympathetic block. It is possible that the plasma concentration of the drug exceeds the concentration required to inhibit gastric acid secretion. This phenomenon is hard to avoid when using traditional methods. The authors applied a new transdermal delivery approach to the anticholinergic drug, scopolamine bromide, using a transdermal device manufactured by CIBA Pharmaceuticals, which allows the drug to be administered at a predetermined rate of control from The skin enters the bloodstream to observe the pair of fingers