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目的:探讨黄芪注射液对尘肺患者的抗氧化作用。方法:用直接硫酸巴比妥酸(TBA)测定方法及黄嘌呤氧化酶测定方法检测40例Ⅰ期尘肺患者在用黄芪注射液治疗前后血清MDA、SOD的含量变化。结果:用黄芪注射液药物后的尘肺患者血清MDA含量明显低于服用黄芪注射液前及不服用黄芪注射液的患者,而血清SOD的活力高于服用前及不服用黄芪注射液的患者,差异有显著性。结论:黄芪注射液细胞能减轻生物膜的类脂质发生的过氧化反应及产生自由基,有良好的抗纤维化作用。
Objective: To investigate the anti-oxidation effect of astragalus injection on patients with pneumoconiosis. Methods: The levels of serum MDA and SOD in 40 patients with stage Ⅰ pneumoconiosis before and after treatment with Astragalus membranaceus were detected by direct determination of barbiturate (TBA) and xanthine oxidase. Results: The content of serum MDA in patients with pneumoconiosis after astragalus injection was significantly lower than that before taking astragalus injection and astragalus injection, while the activity of serum SOD was higher than those before and without astragalus injection, the difference Significant. Conclusion: Astragalus injection cells can reduce lipid peroxidation biofilm and produce free radicals, have a good anti-fibrosis.