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麻醉开胸狗7只,静注常咯啉7mg/kg,血压和左心室作功显著减低,冠脉血流量和主动脉血流量减少不显著,而冠脉阻力有减低趋势。在左心室作功减低时,心肌对氧、乳酸和丙酮酸的利用无明显影响。麻醉开胸结扎左冠状动脉前降支24小时后的清醒狗6只,静脉推注常咯啉5mg/kg对心肌梗塞后室性心律失常有明显的治疗效果,有效时间约半小时左右。对窦性心律的 P-R,QRS 和 Q-T 间期无明显改变。因常咯啉能有效控制狗急性心肌梗塞后的室性心律失常,值得临床试用。
Anesthetic thoracotomy dogs 7, intravenous injection of regular pyrroline 7mg / kg, blood pressure and left ventricular work was significantly reduced, coronary blood flow and aortic blood flow decreased significantly, while the coronary resistance decreased. In the left ventricle to reduce work, myocardial oxygen, lactic acid and pyruvate utilization had no significant effect. Anesthesia Thoracotomy ligation of left anterior descending coronary artery after 24 hours awake dog 6, intravenous injection of regular pyrroline 5mg / kg of myocardial infarction after ventricular arrhythmias have a significant therapeutic effect, the effective time of about half an hour. There was no significant change in the P-R, QRS and Q-T intervals of sinus rhythm. Because of normal pyrroline can effectively control the dog after acute myocardial infarction ventricular arrhythmia, it is worth clinical trial.