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目的:探讨预防性应用抗生素对糖皮质激素治疗老年特发性血小板减少性紫癜并发感染的影响。方法:将哈尔滨医科大学附属第二医院血液科2012年3月~2015年3月的收治的72例老年特发性血小板减少性紫癜患者随机分为两组,自应用糖皮质激素第一天开始观察15天,观察组自应用糖皮质激素开始即使用抗生素,对照组不常规应用抗生素,以出现感染症状即开始应用抗生素,同时定为观察终止。比较两组患者感染发生率的差异。结果:观察组感染发生率为38.89%,对照组为69.44%,较观察组显著升高,差异有统计学意义(P<0.05)。两组患者感染发生部分的分布情况比较无统计学差异(P>0.05),以呼吸系统感染发生率最高,其次是尿路感染。结论:预防性的使用抗生素可以降低糖皮质激素治疗老年特发性血小板减少性紫癜患者过程中感染的发生率。
Objective: To investigate the effect of prophylactic antibiotics on glucocorticoid-induced concurrent idiopathic thrombocytopenic purpura infection. Methods: A total of 72 elderly idiopathic thrombocytopenic purpura patients admitted to Department of Hematology, Second Affiliated Hospital of Harbin Medical University from March 2012 to March 2015 were randomly divided into two groups. From the first day of glucocorticoid treatment, Observation of 15 days, the observation group since the glucocorticoid use of antibiotics, the control group is not routinely used antibiotics, the onset of symptoms that began antibiotics, at the same time as the termination of the observation. Differences in the incidence of infection between the two groups were compared. Results: The incidence of infection in observation group was 38.89% and in control group was 69.44%, which was significantly higher than that in observation group (P <0.05). There was no significant difference in the distribution of infection among the two groups (P> 0.05), with the highest incidence of respiratory infection, followed by urinary tract infection. CONCLUSIONS: Prophylactic antibiotics may reduce the incidence of glucocorticoid in the treatment of elderly patients with idiopathic thrombocytopenic purpura.