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目的应用自建的抗CCP抗体等检测方法,用于类风湿性关节炎(RA)患者的的研究,并分析相应的实验指标与临床的相关性。方法分别检测自身免疫性疾病患者的抗CCP抗体、RF、ANA、CRP和ESR等指标,并了解患者的临床表现及影像学资料。结果 RA患者的抗CCP抗体的阳性率、RF及CRP的水平均显著高于各对照组,差异有统计学意义(P<0.05);RA患者中抗CCP抗体阳性者在关节肿痛数、破坏数和关节外症状方面有较阴性组患者严重的趋势,且抗CCP抗体水平与骨侵蚀程度相关。43例RF阴性的RA患者中有8例(18.6%)其抗CCP抗体明显升高。结论检测抗CCP抗体及相应实验指标,是可用于RA等自身免疫性疾病研究的有效方法,可为临床诊断、评价疗效和预后提供一定的实验室参考依据。
Objective To apply the self-built anti-CCP antibody test method for the study of patients with rheumatoid arthritis (RA), and analyze the corresponding experimental indicators and clinical relevance. Methods Anti-CCP antibodies, RF, ANA, CRP and ESR were detected in patients with autoimmune diseases, and their clinical manifestations and imaging data were analyzed. Results The positive rate of anti-CCP antibody, the level of RF and CRP in RA patients were significantly higher than those in control group (P <0.05). The anti-CCP antibody positive rate in patients with RA was significantly higher than those in control group The number of patients with extra-articular symptoms and the more negative group of patients with a serious trend, and anti-CCP antibody levels associated with the degree of bone erosion. Of the 43 RF-negative RA patients, 8 (18.6%) had significantly higher anti-CCP antibodies. Conclusion The detection of anti-CCP antibody and the corresponding experimental indicators is an effective method for the study of autoimmune diseases such as RA. It can provide some laboratory reference for clinical diagnosis, evaluation of curative effect and prognosis.