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将我院120例慢性乙型肝炎患者分为慢性乙型肝炎组、乙型肝炎肝硬化组,分别进行MELD评分与HOMA-IR等测定并对比分析。结果:乙型肝炎硬化组患者总胆红素(total bilirubin,TBIL)、国际标准化比值(International normalized ratio,INR)、空腹血糖(fasting blood glucose,FPG)、空腹胰岛素(fasting blood insulin,FINS)、HOM A-IR、M ELD评分值均显著高于慢性乙型肝炎组患者;胰岛素敏感指数(Insulin sensitivity index,ISI)显著低于慢性乙型肝炎组患者。HOMA-IR与M ELD评分值呈正相关;ISI与M ELD评分值呈负相关。结论:联合使用M ELD评分、HOM A-IR、ISI指标,能更好的评估慢性乙型肝炎患者的肝病进程,从而更好指导临床的治疗。
120 patients with chronic hepatitis B in our hospital were divided into chronic hepatitis B group and hepatitis B cirrhosis group. The MELD score and HOMA-IR were respectively measured and compared. Results: The total bilirubin (TBIL), international normalized ratio (INR), fasting blood glucose (FPG), fasting blood insulin (FINS) HOM A-IR and M ELD scores were significantly higher than those in chronic hepatitis B patients; Insulin sensitivity index (ISI) was significantly lower than that in patients with chronic hepatitis B. HOMA-IR and M ELD scores were positively correlated; ISI and M ELD scores were negatively correlated. Conclusion: The combination of M ELD score, HOM A-IR and ISI can better assess the course of liver disease in patients with chronic hepatitis B, so as to better guide the clinical treatment.