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蛇床子素和维拉帕米对缩宫素、ＫＣｌ、高Ｋ＋除极化后Ｃａ２＋诱导大鼠离休子宫平滑肌收缩均产生抑制作用，对ＣａＣｌ２累积量效曲线均呈非竞争性拮抗效应，ｐＤ＇２（拮抗多数）分别为３．９±０．１５和７．４５±０．１；１００μｍｏｌ／Ｌ蛇床子素和０．０８μｍｏｌ／Ｌ维拉帕米显著抑制缩宫素诱导依赖细胞内Ｃａ２＋收缩反应，对依赖细胞外Ｃａ２＋的收缩均无明显影响。提示蛇床子素对子宫平滑肌的抑制作用类似维拉帕米，与拮抗Ｃａ２＋有关，且主要通过抑制平滑肌细胞膜上电位依赖性Ｃａ２＋通道和影响胞内Ｃａ２＋释放所致。
Both osthole and verapamil inhibited systolic contraction of uterine smooth muscle after oxytocin, KCl, and high K+ depolarization, and showed a non-competitive antagonistic effect on CaCl2 cumulative dose-response curves. pD’ 2 (antagonistic majority) were 3.9 ± 0.15 and 7.45 ± 0.1, respectively; 100 μmol/L osthole and 0.08 μmol/L verapamil significantly inhibited oxytocin-induced intracellular Ca 2+ contraction The response did not have a significant effect on the contraction of extracellular Ca2+. It is suggested that osthole has inhibitory effect on uterine smooth muscle similar to verapamil, which is related to the antagonism of Ca 2+ and is mainly caused by inhibiting the voltage-dependent Ca 2+ channel on the smooth muscle cell membrane and affecting the release of intracellular Ca 2+ .