β—内酰胺类抗生素和氨基糖苷类抗生素一样是抗生素的领先类群,从中得到许多对抗生素耐药的病原菌有作用的广抗菌谱有开发前途的好药物。β—内酰胺抗生素与氨基糖苷抗生素联合应用是协同作用最成功的实例之一,所以,获得新的β—内酰胺类抗生素好药物将扩大已知氨基糖苷类抗生素应用的可能性。β—内酰胺抗生素是细菌细胞壁合成的 Beta-lactam antibiotics, like aminoglycosides, are leading groups in antibiotics, and many of the promising antimicrobial spectrum to antibiotics-resistant pathogens are promising. The combination of β-lactam antibiotics and aminoglycoside antibiotics is one of the most successful examples of synergistic effects, so obtaining good new β-lactam antibiotics will widen the possibilities of known aminoglycoside antibiotics. Beta-lactam antibiotics are synthesized by bacterial cell walls