小儿呕吐为临床常见病症,目前治疗此症多采用甲氧氯普胺(Metoclo-pramide)给予口服,肌注或双重并用。药理学表明该药可通过阻断脑内多巴胺受体而作用于延脑催吐化学敏感区,具有强大的中枢性镇吐作用,因而在儿科领域中应用相当广泛。然而,小儿因中枢神经系统发育尚不完善,血脑屏障功能较差,对其使用多巴胺受体阻滞剂则能刺激胆碱能受体,使胆碱能受体相对亢进,从而较易导致小儿锥体外系反应发生。由 Pediatric vomiting is a common clinical condition, the current treatment of this disease with metoclopramide (Metoclo-pramide) given orally, intramuscularly or in combination. Pharmacology shows that the drug can block brain dopamine receptors in the brain induced emetic sensitive areas, with central antiemetic antiemetic effect, which is widely used in pediatric fields. However, the children due to the development of the central nervous system is not perfect, the blood-brain barrier function is poor, its use of dopamine blockers can stimulate cholinergic receptors, the relative increase in cholinergic receptors, which is more likely to lead Pediatric extrapyramidal reactions occur. by