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在1965年Gotoff等人发现膜增生性肾小球肾炎病人血清中补体第三成分(C3)减少。1969年Spi-tzer等人将这种病人血中具有裂解C3的活性物质称为C3肾炎因子(C3NeF)。后来又从部分脂质营养不良的病人血清中发现这一类似因子。这一因子之所以能加速C3裂解,经研究一致承认,是由于它能结合到极不稳定的补体第二激活途径的C3转化酶(即C3bBb)上,使该酶的半寿期从4—5分钟延长到160分钟,从而加强了该酶的活性之故。至于这一因子的本质,经证实是一种丙种球旦白,分子量为170,000,由两条相同的多肽链组成,链间由二硫键联系。至于它与免疫球旦白的关系,
In 1965 Gotoff et al. Found a decrease in the third component of complement (C3) in the serum of patients with membranoproliferative glomerulonephritis. 1969 Spi-tzer et al. The active substance with lytic C3 in this patient’s blood is called C3 Nephrin (C3NeF). Later, this lipid-like serum was found in some patients with this lipid-like syndrome. The reason why this factor accelerates the cleavage of C3 is unanimously recognized by the study as it binds to the C3 convertase (ie, C3bBb), which is the second most unstable pathway of complement activation, and changes the half life of the enzyme from 4- 5 minutes to 160 minutes, thus strengthening the activity of the enzyme. As to the nature of this factor, it has been demonstrated to be a globular globular gamma globulin with a molecular weight of 170,000 composed of two identical polypeptide chains with disulfide linkages between the chains. As for the relationship between it and immunoglobulin,