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复方苦参汤是治疗溃疡性结肠炎(UC)大肠湿热证的有效验方~([1-3]),疗效好,副作用少,患者容易接受。复方苦参汤由苦参、青黛、地榆、白及等组成,具有清热燥湿、凉血的的功效。本课题组采用系统溶剂法,将复方苦参汤分为石油醚部位、氯仿部位、乙酸乙酯部位、正丁醇部位和水溶液部位,并采用2、4、6三硝基苯磺酸钠(TNBS)诱导的UC大鼠模型,运用免疫组化、分子生物学等方法,对复方苦参汤治疗UC的有效部位进行筛选,确定了主要有效部
Compound Kushen Tang is the treatment of ulcerative colitis (UC) large intestine damp-heat prescription ~ ([1-3]), good efficacy, fewer side effects, patients are easy to accept. Compound Sophora by Sophora, indigo, Burnet, white and so on, with heat dampness, cooling effect. The research group using the system solvent method, the compound Kushen Tang is divided into petroleum ether, chloroform, ethyl acetate, n-butanol and aqueous solution site, and using 2,4,6 trinitrobenzene sulfonate ( TNBS) induced UC rat model, the use of immunohistochemistry, molecular biology and other methods, the compound Kushen Tang treatment of UC effective parts of the screen to determine the main effective Ministry