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目的:探讨神经肽Y(NPY)与偏头痛的关系。方法:采用放射免疫分析方法对46例偏头痛患者与29例健康人血浆中NPY含量进行了测定。结果:女性病人组NPY含量升高[(38.85±19.43)ng·L~(-1)],与女性对照组[(25.66±14.96)ng·L~(-1)]的差异有极显著意义,与男性病人组[(28.01±11.44)ng·L~(-1)]的差异有显著意义。结论:NPY很可能涉及偏头痛的发病,尤其是女性偏头痛患者的发病过程。
Objective: To investigate the relationship between neuropeptide Y (NPY) and migraine. Methods: Plasma NPY levels in 46 migraineurs and 29 healthy controls were determined by radioimmunoassay. Results: Compared with the female control group [(25.66 ± 14.96) ng · L -1], the NPY content in female patients was significantly higher (38.85 ± 19.43 ng · L -1) , Which was significantly different from that of male patients [(28.01 ± 11.44) ng · L -1]. Conclusion: NPY is likely to be involved in the incidence of migraine, especially in women with migraine.