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许多研究已证明,前列腺素(PGE)对SLE 鼠模型的免疫复合物型肾小球肾炎。(ICGN)有很好的治疗效果。然而,人们还了解PGE对这种鼠模型作用的准确机制。为了解PGE_2如何缓解鼠的免疫复合物型肾小球肾炎的发展,作者对用阿朴铁蛋白制造鼠的ICGN模型进行了实验。实验共分6组。每组10只鼠。第一组每日腹腔注入4mg 阿朴铁蛋白。第2—5组每日注射4mg阿朴铁蛋白,同时每日两次(Bid)皮下分别注射PGE_2 200μg、100μg、50μg、25μg。第6组每日注射0.2ml盐水于腹腔中。注射进行4周。在注射前、注射后2周、4周,采鼠24小时尿,测定其尿蛋白。在末次注射4天后处死小鼠,收集血清,测定抗阿朴铁蛋白抗体;取其肾脏制备
Numerous studies have demonstrated that prostaglandin (PGE) is an immunocomplex-type glomerulonephritis of the SLE murine model. (ICGN) has a good therapeutic effect. However, one also understands the precise mechanism by which PGE acts on this murine model. To understand how PGE 2 can ameliorate the development of murine immune complex glomerulonephritis, the authors performed experiments on the ICGN model of mice made from apoprotein. The experiment is divided into 6 groups. 10 rats in each group. The first group daily intraperitoneal injection of 4mg apoprotein. Groups 2-5 were injected daily with 4 mg of apoprotein, and 200 μg, 100 μg, 50 μg and 25 μg of PGE 2 were injected subcutaneously twice a day (Bid). Group 6 daily injection of 0.2ml saline in the abdominal cavity. Inject for 4 weeks. Before injection, 2 weeks after injection, 4 weeks, mice were 24 hours urine, urine protein was measured. The mice were sacrificed 4 days after the last injection, the serum was collected and the anti-apo-ferrin antibody was measured; their kidneys were prepared