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作者合成了一系列具有与鼻病毒复制抑制剂4＇,6-二氯黄烷(BW 638C)和WIN化合物结构类似的黄酮化合物。在黄烷、异黄烷以及异黄烯(isoflavenes)的4＇和/或6位上用氯和/或氰基、脒基、噁唑啉环取代得到这些新黄酮成分。这些化合物的抗病毒活性用IB型人鼻病毒感染的HeLa细胞导致的细胞坏死和空斑形成试验进行测定,结果均显示活性。氰基和氯取代物较脒基、噁唑啉衍生物活性更强。4＇,6-二氰基黄烷(DCF)的作用比BW 638C稍强,4＇-氯-6-氰基黄烷的活性为
The authors synthesized a series of flavonoids with structures similar to those of the rhinovirus replication inhibitor 4 ’, 6-dichloro flavan (BW 638C) and WIN compounds. These new flavonoid components are obtained by replacement of the flavan, isoflavine and the 4 ’and / or 6 position of isoflavenes with chlorine and / or cyano, amidino, oxazoline rings. The antiviral activity of these compounds was determined by a cell necrosis and plaque formation assay caused by HeLa cells infected with IB type human rhinovirus and the results showed activity. Cyano and chloro substitutions are more active than amidino and oxazoline derivatives. 4 ’, 6-dicyanoflavan (DCF) is slightly stronger than that of BW 638C and the activity of 4’-chloro-6-cyanoflavan is