Ｓｊｏｇｒｅｎ综合征（ＳＳ）好发于女性，由于较多患者早期症状不典型，可无口眼干燥、无腮腺肿大，往往导致漏诊误诊。少数ＳＳ以某一系统损害为突出表现，或以肝脾肿大、高球蛋白血症而干扰诊断。唾液腺、泪腺功能检查、腮腺造影、下唇唇腺活检是必不可少的诊断方法。本文对原发性ＳＳ的诊断，ＳＳ系统性损害的诊断及合并其他自身免疫病的诊断进行了初步的讨论。 Sjogren’s syndrome (SS) occurs in women, because more patients with atypical early symptoms, no dry mouth, no parotid gland enlargement, often leading to misdiagnosis. A small number of SS to a system of outstanding performance, or hepatosplenomegaly, hypergammaglobulinemia and interference diagnosis. Salivary gland, lacrimal gland function examination, parotid gland, lower lip labial biopsy is an essential diagnostic method. This article has a preliminary discussion on the diagnosis of primary SS, the diagnosis of systemic SS damage and the diagnosis of other autoimmune diseases.