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作者根据以前对海群生分子结构的研究,合成了一些1-甲基-4-羰基烷氧基哌嗪类化合物,经实验发现其中的1-异构-丁氧基羰基-4-甲基哌嗪(6a)具有杀丝虫微丝蚴和成虫的作用。按照Hawking等(1948)描述的方法,使棉鼠感染棉鼠丝虫。药物抗棉鼠丝虫微丝蚴及成虫的效果,根据Lammber等(1971)制订的标准进行评价。实验动物每组3或4鼠,所用剂量相当于小鼠最大耐受剂量的1/5,腹腔注射,连续6天。除小鼠于给药后72天灭死,以观察成虫活力外,用相同方法观察药物抗纳塔耳多乳鼠体内魏氏棘唇丝虫(Di-
Based on the previous study on the molecular structure of the sea qun, some 1-methyl-4-carbonylalkoxy piperazines have been synthesized and found that 1-isobutyl-4-methylpiperazine The oxazine (6a) has the effect of controlling filarial microfilariae and adults. Cotton rats were infected with the fibroids in accordance with the method described by Hawking et al. (1948). The efficacy of the drug against microfilarea and adults of M. gonorrhoeae was evaluated according to the criteria established by Lammber et al. (1971). Three or four mice in each group were dosed with one-fifth of the maximum tolerated dose of the mice and injected intraperitoneally for 6 consecutive days. Except that the mice were sacrificed 72 days after administration to observe the viability of the adult mice, the same method was used to observe the effects of the drug against Di-