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噻唑啉酮是一个主要由碳、氮及硫原子组成的杂环体系.它是一种优势骨架结构,可与多种生物大分子结合,产生广泛的生物活性,如抗肿瘤、抗茵、抗寄生虫、抗炎和抗结核分枝杆菌等.近年来,微波法及离子液体法等新的合成手段被广泛地应用于噻唑啉酮衍生物的合成中,使得噻唑啉酮衍生物的结构类型及生物活性更加多样化.笔者结合自己的工作,在查阅文献的基础上,对噻唑啉酮衍生物的合成方法以及近5年内新型噻唑啉酮衍生物的生物活性作以简要的介绍,为将来新型噻唑啉酮类化合物的研发提供参考.“,”Thiazolidinone is a heterocyclic system comprising carbon atoms,nitrogen atom and sulphur atom.As a key skeleton structure,it can produce a variety of biological activities by combining with biological macromolecules,such as antitumor,antisepsis,antiparasitic,anti-inflammatory and antimycobacterial effects,etc.Recently,microwave method and ionic liquid method were applied in the synthesis of thiazolidinone derivatives.Thus,the structure types and biological activities of thiazolidinone derivatives were more diversified.In this paper,combining with our previous work and referring to literatures,the synthetic methods and new thiazolidinone derivatives in the recent five years were briefly introduced.These can provide evidence for further development of novel thiazolidinone derivatives.