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(一)洋地黄类药物的用法 洋地黄类药物的传统用法是在一定时间(24～74小时)内给予洋地黄制剂的饱和量,以达到强心作用。洋地黄饱和量与中毒量较接近,约为中毒量的60％,实践证明,按因传统方法用药,洋地黄中毒的发生率可达20％以上。晚近的研究结果显示,洋地黄的正性肌力作用与剂量呈线性关系,即小剂量就有增强心肌收缩力的作用,心肌收缩力随着剂量增加而加强。基于此事实,治疗心力衰竭的洋地黄剂量就不要求达到饱和量,而是根据患者的具体情况及心脏的功能状态而定,即个体化原则。用洋地黄后凡能有效地控制心力衰竭,则认为已达洋地黄化。洋地黄的剂量应较传统用量为小,在1～3日内给予洋地黄化量,随后给予维持量。在2周内未用过慢作用制剂,1周内未用过快作用制剂者,
(A) the use of digitalis drugs Traditional use of digitalis drugs in a certain period of time (24 to 74 hours) to give digitalis saturation, in order to achieve a cardiac effect. Digitalis saturates with the amount of poisoning is close to about 60% of the amount of poisoning, practice has proved that, according to the traditional method of medication, the incidence of digitalis poisoning up to 20%. Recent studies have shown that the positive inotropic effect of digitalis and dose was linear, that is, a small dose of myocardial contractility can enhance the role of myocardial contractility increased with dose. Based on this fact, the dose of digitalis for the treatment of heart failure does not require saturation and is based on the patient’s condition and the functional status of the heart, ie the principle of individualization. With digitalis who can effectively control heart failure, then that has reached ocean yellow. The dose of digitalis should be less than the traditional amount, giving digitalis within 1 to 3 days, followed by maintenance dose. In 2 weeks did not use a slow-acting agents, 1 week did not use fast acting agents,