The Pharmacological activities of the aqueous extract from the stem of U. macrorrhiza on nociceptive response using writhing, hot plate and formalin test in mice and the antipyretic activity in yeast-induced fever, anti-inflammatory effect in carageenin induced paw edema in rats, were examined. The LD50 value of intraperitoneally injected U. macrorrhiza stems extract in mice was 0.82 g/kg. Oral administration of the aqueous extract from the stem U. macrorrhiza (100-400 mg/kg) dose dependently reduced the number of writhings and stretchings induced by acetic acid and decreased licking activity of the late phase in formalin test (200～400mg/kg), but not heat induced pain. The extract from the stem of U. macrorrhiza (200～400mg/kg) suppressed yeast-induced fever in rats, It (100mg/kg) also reduced an acute paw edema induced carageenin induced paw edema in rats. These results suggest that the extract from the stem of U. macrorrhiza possesses peripheral analgesic antipyretic effect and anti-inflammatory effects. The Pharmacological activities of the aqueous extract from the stem of U.macrorrhiza on nociceptive response using writhing, hot plate and formalin test in mice and the antipyretic activity in yeast-induced fever, anti-inflammatory effect in carageenin induced paw edema in rats, were Examined. The LD50 value of intraperitoneally injected U. macrorrhiza stems extract in mice was 0.82 g/kg. Oral administration of the aqueous extract from the stem U. macrorrhiza (100-400 mg/kg) dose dependently reduced the number of writhings and stretchings Induced by acetic acid and decreased licking activity of the late phase in formalin test (200～400mg/kg), but not heat induced pain. The extract from the stem of U. macrorrhiza (200～400mg/kg)controlled yeast-induced fever In rats, It (100mg/kg) also reduced an acute paw edema induced carageenininduced paw edema in rats. These results suggest that the extract from the stem of U. macrorrhiza possesses peripheral analgesic antipyretic effect and Anti-inflammatory effects.