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目的探讨三维适形放射治疗联合力扑素(LPS)周化疗对宫颈癌腹主动脉旁淋巴结转移的短期疗效和不良反应。方法 64例宫颈癌腹主动脉旁淋巴结转移患者分为单纯放疗组和联合治疗组,每组各32例,两组患者均给予适形放疗,20 Gy/f,每周5次,腹主动脉旁总剂量60 Gy。联合治疗组在三维适形放疗的同时,行力扑素周化疗,每周60 mg/m2,连续3周为1个周期,2个周期后间隔1周。观察临床效果和不良反应。结果单纯放疗组的总有效率为56.3%,临床控制率为81.3%;联合治疗组的总有效率为81.3%,临床控制率为93.8%。两组总有效率差异有统计学意义(P<0.05)。联合治疗组患者白细胞减少的发生率高于单纯放疗组(P<0.05),血小板减少、过敏反应和感觉异常等不良反应发生率差异无统计学意义(P>0.05)。结论三维适形放疗联合力扑素周化疗能够显著增强宫颈癌腹主动脉旁淋巴结转移的近期疗效,除白细胞减少,其他不良反应未见明显增加。
Objective To investigate the short-term curative effect and adverse reactions of three-dimensional conformal radiotherapy combined with LPS peripheral chemotherapy on para-aortic lymph node metastasis of cervical cancer. Methods 64 cases of cervical cancer with para-aortic lymph node metastasis were divided into radiotherapy group and combination therapy group, 32 cases in each group. Both groups received conformal radiotherapy, 20 Gy / f, five times a week, abdominal aorta Next to the total dose of 60 Gy. Combination therapy group in the three-dimensional conformal radiotherapy at the same time, force phyllotaxin weekly chemotherapy 60 mg / m2, 3 consecutive weeks as a cycle, 2 cycles after an interval of 1 week. To observe the clinical effects and adverse reactions. Results The total effective rate in radiotherapy alone group was 56.3% and clinical control rate was 81.3%. The total effective rate in combination therapy group was 81.3% and clinical control rate was 93.8%. The total effective rate between the two groups was statistically significant (P <0.05). The incidence of leukopenia in the combination therapy group was higher than that in the radiotherapy alone group (P <0.05). The incidence of thrombocytopenia, anaphylaxis and sensory abnormalities had no statistical significance (P> 0.05). Conclusion Three-dimensional conformal radiotherapy combined with puerarin chemotherapy can significantly enhance the short-term curative effect of para-aortic lymph node metastasis of cervical cancer. Except for leukopenia, other adverse reactions have not been significantly increased.