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目的 观察中药大黄对大鼠急性出血性胰腺炎的作用以及对胰腺外分泌功能的影响。方法 采用铃蟾肽加水浸束缚应激的方法诱导大鼠急性出血性胰腺炎 ,经口灌服大黄醇抽提物 75～ 150mg/kg 2次。观察血清淀粉酶、胰腺湿重、胰腺血流量及胰腺组织病理改变 ;并观察大黄与奥曲肽对胰液外分泌功能的影响。结果 大黄治疗组的胰腺坏死和中性粒细胞浸润明显减轻 ;胰腺湿重、血清淀粉酶活性和胰腺血流量均有剂量依赖性改善。胰腺炎组大鼠胰液流量、胰液蛋白含量均明显下降 ,胰液碳酸氢根含量没有明显改变 ,大黄治疗组胰液淀粉酶活性明显降低 ,与奥曲肽治疗组比较无统计学差异 ,其胰液碳酸氢根含量明显升高 ,奥曲肽则无此作用。结论 大黄可有效改善大鼠急性出血性胰腺炎的严重程度 ,与抑制胰腺炎性反应、改善胰腺血流量和抑制胰酶分泌、促进胰液引流等多靶位作用有关
Objective To observe the effect of rhubarb on acute hemorrhagic pancreatitis in rats and its effect on pancreatic exocrine function. Methods Acute hemorrhagic pancreatitis was induced by bombardin and water-immersed restraint stress, and the extract of rhubarb was orally administered 75-150 mg/kg 2 times. The serum amylase, pancreatic wet weight, pancreatic blood flow and pathological changes of pancreas were observed. The effects of rhubarb and octreotide on the exocrine function of pancreatic juice were observed. Results The pancreatic necrosis and neutrophil infiltration of the rhubarb treatment group were significantly relieved; the pancreas wet weight, serum amylase activity and pancreatic blood flow were all dose-dependently improved. Pancreatic fluid flow and protein content in pancreatic juice were significantly decreased in pancreatitis rats. The bicarbonate content in pancreatic juice did not change significantly. The activity of amylase in pancreatic juice was significantly decreased in the treatment group of rhubarb. There was no statistical difference between octreotide treatment group and its bicarbonate bicarbonate level in pancreatic juice. Obviously increased, octreotide does not have this effect. Conclusion Rhubarb can effectively improve the severity of acute hemorrhagic pancreatitis in rats, which is related to the inhibition of pancreatic inflammatory reaction, improvement of pancreatic blood flow, inhibition of pancreatic enzyme secretion, and promotion of drainage of pancreatic juice.