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呋硫硝胺(Ranitidine)是一种新型 H_2受体阻滞剂,它由呋喃环置换甲氰咪胍中的咪唑环而成。临床上的止酸效果为甲氰咪胍的4～9倍,且作用持续时间较长。静脉注射呋硫硝胺20mg/8h 和20mg/4h 后,平均胃内 pH 分别上升至7.0及6.3,83%的病人在24小时内 pH>5。胃内 pH 值上升是治疗上消化道出血的必要条件。由于盐酸分泌抑制,胃蛋白酶原不能被激活,H~+逆弥做减少,血液凝固机制得以改善,细胞膜电位升高,溶酶体酶逸出减少。从而有利于上消化道出血的治疗及预防。本文报告用呋硫硝胺治疗上消化道出血,剂量为静滴呋硫硝胺50mg/h,每日4次。止血后口服150
Ranitidine (Ranitidine) is a new H 2 receptor blocker, which consists of furan ring replacement of cimetidine imidazole ring formed. Clinic acid effect of cimetidine 4 to 9 times, and the role of longer duration. Intravenous furilamine 20mg / 8h and 20mg / 4h, the average intragastric pH increased to 7.0 and 6.3, 83% of patients within 24 hours pH> 5. Increased gastric pH is necessary for the treatment of upper gastrointestinal bleeding. Due to inhibition of hydrochloric acid secretion, pepsinogen can not be activated, H ~ + inverse Mi to reduce, blood coagulation mechanism can be improved, the cell membrane potential increased, lysosomal enzyme escape reduced. Which is conducive to the treatment and prevention of upper gastrointestinal bleeding. This article reports furosemide nitration treatment of upper gastrointestinal bleeding, the dose of intravenous furunamide 50mg / h, 4 times a day. Oral 150 after hemostasis