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孙氏“乌龙活骨膏”由艾叶、肉桂、乌梢蛇、川乌、血竭、地龙等18味纯中药组成,主要用于股骨头无菌性坏死的外敷治疗,临床已应用多年,为了确保用药安全有效,进行了皮肤急性毒性及刺激性试验,现报告如下:1.皮肤急性毒性试验 取健康体重为2～2.5kg白色家兔9只,♂、♀兼有,分为三组,每组3只,于实验前24h后用脱毛剂在脊柱两侧各脱毛6×9cm第一组为正常皮肤给
Sun’s “Oolong Live Bone Paste” is composed of 18 kinds of pure Chinese herbal medicines such as artemisia, cinnamon, Zaocys dhumna, Chuanwu, Dragon’s Blood, and Earthworm. It is mainly used for the external application of aseptic necrosis of the femoral head, and has been used clinically for many years. In order to ensure the safe and effective use of the drug, an acute toxicity and irritation test of the skin was performed. The report is as follows: 1. Acute skin toxicity test 9 healthy white rabbits weighing 2 to 2.5 kg were used. Groups, 3 in each group, were depilated with hair removal agents on both sides of the spine 6x9cm 24 hours before the experiment. The first group was normal skin