单一免疫球蛋白白细胞介素1受体相关蛋白(SIGIRR,或TIR8)是Toll-IL-1受体(TIR)超家族的成员之一[1]。它广泛分布于被覆上皮组织的器官,如肾脏、肺、结肠等,并且可以负性调节白细胞介素1受体(IL-1R)、Toll样受体(TLRs)介导的固有免疫应答[2]。固有免疫是机体防御病原体的第一道防线,对适应性免疫也起到调节作用。固有免疫反应过度可导致炎症因子瀑布样释放,从而造成对机体的损害[3]。因此固有免疫的负性调节对 The single immunoglobulin interleukin 1 receptor related protein (SIGIRR, or TIR8) is a member of the Toll superfamily of Toll-1 (TIR) ​​[1]. It is widely distributed in epithelial tissues such as kidneys, lungs, colon, etc. and can negatively regulate the innate immune response mediated by interleukin-1 receptor (IL-1R) and Toll-like receptors (TLRs) [2 ]. Innate immunity is the body’s first line of defense against pathogens, also play a regulatory role in adaptive immunity. Inherent immune response can lead to inflammatory factor waterfall-like release, resulting in damage to the body [3]. Therefore, the negative regulation of innate immunity