This article aims at designing a new Multivariate Quadratic (MQ) public-key scheme to avoid the linearization attack and differential attack against the Matsumoto-Imai (MI) scheme. Based on the original scheme, our new scheme, named the Multi-layer MI (MMI) scheme, has a structure of multi-layer central map. Firstly, this article introduces the MI scheme and describes linearization attack and differential attack; then prescribes the designation of MMI in detail, and proves that MMI can resist both linearization attack and differential attack. Besides, this article also proves that MMI can resist recent eXtended Linearization (XL)-like methods. In the end, this article concludes that MMI also maintains the efficiency of MI. This article aims at designing a new Multivariate Quadratic (MQ) public-key scheme to avoid the linearization attack and differential attack against the Matsumoto-Imai (MI) scheme. Based on the original scheme, our new scheme, named the Multi-layer MI (MMI) scheme, has a structure of multi-layer central map. Firstly, this article introduces the MI scheme and describes linearization attack and differential attack; then prescribes the designation of MMI in detail, and proves that MMI can resist both linearization attack and differential attack. Besides, this article also proves that MMI can resist recent eXtended Linearization (XL) -like methods. In the end, this article concludes that MMI also maintains the efficiency of MI.