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背景.双胎使脑性瘫(CP)发病的危险性更大,而美国和世界各地双胎的发生率正在不断增加,本文旨在揭示双胎与脑性瘫之间的相关关系。方法.在加利福尼亚北部4个县155572名出生于1983～1985年的儿童中,凡被诊断为中度或严重程度先天性CP,且幸存至3岁者均列为研究对象.对双胎儿童CP的发生率和一些同CP有关的危险因素进行调查。结果.在2985例双胎儿中,18对中的20例为CP。CP的发生率为6.7/1000个3岁双胎儿(95％可信限CI为4.2～11);12/1000个双胎妊娠(95％CI为7.2～19);1.1/1000个单胎儿(95％CI为0.97～1.3)。所有CP儿中10％为双胎儿,出生体重<1500g的CP儿中,22％为双胎儿。双胎儿占极低出生体重儿(VLBW)的绝大多数,但其出现CP的危险性同VLBW单胎儿相当。出生体重≥2500g的双胎
Background Twins are at greater risk for developing cerebral palsy (CP), while the incidence of twins in the United States and around the world is on the rise, and this article aims to reveal the association between twins and cerebral palsy. METHODS: Of the 155,572 children born in 1983-85 in four districts of northern California, subjects with congenital CP who were diagnosed as having moderate or severe congenital CP and who survived until age 3 were enrolled in the study. Incidence and some of the CP-related risk factors to investigate. Results Of the 2985 twin fetuses, 20 of 18 were CP. The incidence of CP was 6.7 per 1,000 live births (95% CI 4.2 to 11); 12/1000 twin pregnancies (95% CI 7.2-19); and 1.1 / 1000 single fetuses 95% CI 0.97 ~ 1.3). 10% of all CP children were twins and 22% of twins were born with CPs weighing <1500g. Twins comprise the vast majority of very low birth weight infants (VLBW), but their risk of developing CP is comparable to that of VLBW single fetuses. Birth weight ≥ 2500g twins