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目的:观察GnRHa触发排卵的临床效果。方法:回顾性分析328例多囊卵巢综合征患者1259个促排卵周期,随机分组,当直径≥16mm卵泡>6个和/或卵巢直径≥6cm,归入试验组,试验组曲普瑞林0.1mg皮下注射,1次/日(n=736周期);对照组绒促性素10000U肌肉注射,1次/日(n=523周期)。比较两组的治疗结果。结果:两组平均年龄、不孕年限、基础内分泌情况、排卵日子宫内膜厚度比较,无统计学差异(P>0.05);两组排卵率、妊娠率、多胎妊娠率比较,无统计学差异(P>0.05),中重度OHSS发生率比较,组间有统计学差异(P<0.05);两组排卵数比较,有统计学差异(P<0.05);优势卵泡个数分层比较,两组排卵率无统计学差异(P>0.05)。结论:0.1mgGnRHa诱发排卵的排卵率、妊娠率与HCG组相似,能有效的降低OHSS发生;但GnRHa诱发排卵组,排卵数多于HCG组,妊娠率及多胎妊娠数与HCG组相似,可能与GnRHa诱发排卵后的黄体缺陷有关。
Objective: To observe the clinical effect of GnRHa in triggering ovulation. Methods: A total of 1259 ovulation cycles of 328 PCOS patients were retrospectively analyzed. Randomly divided into groups of 6 ovarian follicles (≥16 mm in diameter) and / or ≥ 6 cm in ovary diameter were included in the test group. Triptorelin 0.1 mg Subcutaneous injection, 1 time / day (n = 736 cycles); control group villus procambilin 10000U intramuscular injection, 1 time / day (n = 523 cycles). The results of the two groups were compared. Results: There was no significant difference in average age, infertility duration, basic endocrine status and endometrial thickness on ovulation day (P> 0.05). There was no significant difference in ovulation rate, pregnancy rate and multiple pregnancy rate between the two groups (P> 0.05). The incidence of moderate-severe OHSS was significantly different between the two groups (P <0.05). There was a significant difference in the number of ovulation between the two groups (P <0.05) There was no significant difference in ovulation rate between the two groups (P> 0.05). Conclusions: Ovulation rate and pregnancy rate induced by 0.1mg GnRHa are similar to those in HCG group, which can effectively reduce the incidence of OHSS. However, the number of ovulation induced by GnRHa and the number of ovulation in HCG group were similar, and the pregnancy rate and number of multiple pregnancy were similar GnRHa induced luteal defect after ovulation.