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Imipenem-cilastatin(亚胺硫霉素-脱氢肽酶抑制剂)钠盐被称为最广谱的抗生素,已被批准静脉注射,用于治疗不明病因的感染、重病患者的混合感染和医院内感染。这种被称为β-内酰胺的药物具有较高的抗革兰氏阴性和革兰氏阳性需氧及厌氧菌活性,几乎对身体每个部位的感染都有效。一般情况下,单一用药效果较好该药能否保持长期效力或代替青霉素至今尚未定论。 Imipenem为硫霉素的一种类似物,是产生于cattleya链霉菌的一种β-内酰胺抗生素。cilastatin是肾脱氢肽酶的强效抑制剂,并能在泌尿道发挥抗菌作用。这使该药成为碳青霉烯抗生素的一种新类型,在化学和生物学上都不同于青霉素类和头孢菌素类。
The salt of Imipenem-cilastatin, the most widely used antibiotic, has been approved for intravenous injection for the treatment of infections of unknown etiology, mixed infections in seriously ill patients and in hospitals infection. This beta-lactam-based drug has high resistance to Gram-negative and Gram-positive aerobic and anaerobic bacteria and is effective at affecting almost every part of the body. Under normal circumstances, a single drug is better The drug can maintain long-term efficacy or replace penicillin has not yet been conclusive. Imipenem, an analog of thiophanmycine, is a beta-lactam antibiotic produced by Streptomyces cattleya. cilastatin is a potent inhibitor of renal dehydropeptidase and exerts an antimicrobial effect in the urinary tract. This makes the drug a new type of carbapenem antibiotic, both chemically and biologically different from penicillins and cephalosporins.